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A textbook assumption about the brain’s most abundant receptors needs to be rewritten

  • RESEARCH BRIEFINGS

The AMPA group of brain receptors have mostly been assumed to be calcium impermeable and so were not thought to contribute to the calcium-dependent mechanisms underlying learning and memory. Observations of calcium permeability in some AMPA-receptor subtypes now overturn those assumptions about these receptors’ properties and their roles in neuronal communication.


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